Autologous Stem Cell Therapy for Autism Spectrum Disorders
INTRODUCTION
Autologous Stem Cell Therapy for Autism Spectrum Disorders
Introduction Autologous stem cell therapy is an innovative therapeutic approach for children with autism spectrum disorders (ASD). Over the past couple of decades this therapy has consistently shown to improve the outcomes in Autism. The Stem cell therapy requires cutting edge technology with advanced specialised clinical and technical skills to be implemented successfully. The stem cells are separated and prepared by highly skilled personnel in an extremely sterile ISO 7 environment. This is a very delicate work requiring years of education and training. This is one major reason why this therapy is not available widely. Iffat Anwar Medical Complex is the first and, to the best of our knowledge, only Punjab Healthcare Commission approved regenerative therapy centre. Our standards are assessed by the American Board of Regenerative Medicine and we are very proud of getting the status of Partner facility by American Board of Regenerative Medicine.
AUTISM SPECTRUM DISORDER
Autism Spectrum Disorder (ASD) is a neuro-developmental disorder that affects
communication, social interaction, and behavior. Effected persons show a wide
range of symptoms. In individuals with Autism Spectrum Disorder (ASD), there
are notable differences in brain function. These differences are observed through
various neuroimaging techniques such as MRI (Magnetic Resonance Imaging),
EEG (Electroencephalography), fMRI (functional Magnetic Resonance Imaging)
and PET (positron emission tomography) scan.
The changes in brain function associated with autism are complex and
multifaceted, involving alterations in connectivity, structure, neurotransmitter
levels, and sensory processing. Each child is effected differently leading diverse
range of symptoms and behaviours. MRI and PET scans has shown some areas of
brain are less active in ASD. In addition, the biological evidence of inflammation
in the brain of an ASD effected indicated is established in multiple studies.
In his study, Arking (2014) says, the research team was able to narrow in on a
specific type of support cell known as a microglial cell, which polices the brain
for pathogens and other threats. In the autism brains, the microglia appeared
to be perpetually activated, with their genes for inflammation responses turned
on. This inflammation is considered a major mechanism leading to Autism.
WHAT ARE STEM CELLS?
Stem cells are special types of cells in the human body that have the remarkable
ability to develop into many different cell types. They serve as a sort of internal
repair system, capable of dividing and renewing themselves for long periods.
WHAT IS THE ROLE OF STEM CELL IN BODY?
Stem cells play several crucial roles in the body, contributing to development,
growth, tissue repair, and maintenance. Here are some key roles of stem cells:
1.Development: Stem cells are essential during embryonic development, as they
give rise to all the different cell types that make up the body. Embryonic stem cells
have the ability to differentiate into any cell type, which is vital for the formation
of tissues, organs, and systems within the developing embryo.
2.Tissue Repair and Regeneration: Adult stem cells are involved in tissue repair
and regeneration throughout life. When tissues are damaged due to injury or
disease, stem cells are activated to proliferate and differentiate into the specific
cell types needed to replace the damaged cells. This process is essential for
maintaining the integrity and function of various tissues and organs in the body.
3.Homeostasis: Stem cells contribute to the maintenance of homeostasis, which is
the stable internal environment necessary for the body's proper functioning. They
continuously replenish cells that are lost through normal wear and tear, ensuring
that tissues and organs remain functional over time.
4.Immune System Support: Certain types of stem cells, such as hematopoietic
stem cells found in the bone marrow, are responsible for generating new blood
cells, including white blood cells that are vital for the body's immune response.
These stem cells play a crucial role in maintaining the body's ability to fight off
infections and diseases.
Overall, the diverse roles of stem cells underscore their importance in both normal
physiological processes and potential therapeutic applications for treating a wide
range of diseases and disorders.
Benefits of Autologous Stem Cell Therapy for Autism
Stem cell therapy may lead to improvements in core symptoms of autism. Some are as following;
1. Behavioural Improvements:
Studies have reported a decrease in aggressive behaviour, hyperactivity, and repetitive actions in children who received autologous stem cell therapу. Moreover, improved eye contact, attention span, and communication skills have also been observed
2. Cognitive Function:
There's potential for stem cell therapy to enhance cognitive function and learning ability, which could help individuals with autism to process information more effectively. Research suggests that stem cell transplantation may lead to cognitive improvements, including reduced cognitive rigidity. Enhancements in memory, learning, and problem-solving abilities are areas of interest.
3. Social Functioning
Autologous stem cell therapy positively impacts social behaviour and interaction. Children receiving this therapy have shown better social engagement and increased responsiveness
4. Daily Living Skills
Increased independence in daily living skills is another
possible benefit, allowing individuals with autism to perform everyday tasks with
greater ease.
5. Gastrointestinal
Issues: Many individuals with autism experience
issues. Stem cell therapy might reduce inflammation and food sensitivities, leading to better overall health.
6.Combination with Psychological Interventions:
A clinical trial has shown that combining psychological interventions with Autologous stem cell therapy can significantly
assist children diagnosed with ASD, suggesting a synergistic effect when used alongside traditional therapies. According to researches the autologous stem cell therapy increases the effectiveness of further speech, behavioral and occupational therapy.
7. Safety and Tolerability:
The available evidence indicates that autologous stem cell therapy is generally safe and well-tolerated. When compared to placebo no serious Adverse reactions were noted. The reported side effects were comparable to those in control groups.
OUR TEAM
DR. HAMMAD ANWAR TIRMIZI
Dr Hammad Anwar Tirmizi
MBBS, MRCP (UK), MRCGP (UK), AFMCP (US),
MSc (University of Oxford, UK),
Diplomat of the American Board of Regenerative Medicine (DABRM, USA)
DR. HAMMAD ANWAR TIRMIZI
Dr Irfan Karamat
MSc Psychology, MS Clinical Psychology,
Diploma in Early Childhood Development,
Certification in understanding the Autism Spectrum Disorder & Unraveling the Mystery
DR. HAMMAD ANWAR TIRMIZI
Dr Zaigham
MSc, PHD (Queens University Nottingham UK), DABRM (Diplomat American Board of Regenerative Medicine)
MRS GHAZAL ZAIDI
Ghazal Zaidi
Consultant Clinical Psychologist MSc Applied Psychology MPhil Applied Psychology Advance Diploma in Clinical Psychology
DR. HAMMAD ANWAR TIRMIZI
DN Sabiqa
Clinical Dietitian in Regenerative medicine and Stem cell therapy for Autism BSc. Nutrition and Dietetics (UVAS)
DR. HAMMAD ANWAR TIRMIZI
Hussain Rana
MSc Psychology, MS Clinical Psychology, Diploma in Early Childhood Development, Certification in understanding the Autism Spectrum Disorder & Unraveling the Mystery
